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Synfacts 2005(0): 0013-0013
DOI: 10.1055/s-2005-865339
DOI: 10.1055/s-2005-865339
Synthesis of Natural Products and Drugs
© Georg Thieme Verlag Stuttgart · New YorkTotal Synthesis of Caprazol
S. Hirano, S. Ichikawa, A. Matsuda*
Hokkaido University, Japan
Further Information
Publication History
Publication Date:
20 July 2005 (online)
Significance
Caprazol is the core structure of the Caprazamycin antibiotics. The Caprazamycins are isolated from Streptomyces sp MK730-62F2. They inhibit Mra Y, a key enzyme in peptidoglycan synthesis in Mycobacterium tuberculosis. They have no significant toxicity to mice.