Total Synthesis of Aureothin and N-Acetylaureothamine

M. F. Jacobsen; J. E. Moses; R. M. Adlington; J. E. Baldwin

doi:10.1055/s-2005-865349

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Synfacts 2005(0): 0009-0009
DOI: 10.1055/s-2005-865349

Synthesis of Natural Products and Drugs

Total Synthesis of Aureothin and N-Acetylaureothamine

Contributor(s): Philip Kocienski
M. F. Jacobsen, J. E. Moses, R. M. Adlington, J. E. Baldwin*
Oxford University, UK

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Publication History

Publication Date:
20 July 2005 (online)

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Significance

Aureothin is an unusual nitroaryl metabolite of Streptomyces netropis. It has antitumor, antifungal and pesticidal activity. N-Acetylaureothamine is active against Helicobacter pylori, the cause of chronic gastritis.