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Synfacts 2005(0): 0009-0009  
DOI: 10.1055/s-2005-865349
Synthesis of Natural Products and Drugs
© Georg Thieme Verlag Stuttgart · New York

Total Synthesis of Aureothin and N-Acetylaureothamine

Contributor(s): Philip Kocienski
M. F. Jacobsen, J. E. Moses, R. M. Adlington, J. E. Baldwin*
Oxford University, UK
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Publication History

Publication Date:
20 July 2005 (online)

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Significance

Aureothin is an unusual nitroaryl metabolite of Streptomyces netropis. It has anti­tumor, antifungal and pesticidal activity. N-Acetyl­aureothamine is active against Helicobacter pylori, the cause of chronic gastritis.