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Synfacts 2005(0): 0019-0019
DOI: 10.1055/s-2005-865378
DOI: 10.1055/s-2005-865378
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Diversely Functionalized Hexa-hydropyrrolo[2,3-b]indoles
T. Kawasaki*, A. Ogawa, R. Terashima, T. Saheki, N. Ban, H. Sekiguchi, K. Sakaguchi, M. Sakamoto
Meiji Pharmaceutical University, Tokyo, Japan
Further Information
Publication History
Publication Date:
20 July 2005 (online)
Significance
The synthesis of hexahydropyrrolo[2,3-b]indoles from indolin-3-ones which incorporates a three-step domino sequence is reported. The sequence is a new, general, and reason-ably efficient (48-88%) synthesis which allows introduction of elements of diversity at the quaternary carbon site of the pyrrolo[2,3-b]indole ring system.