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Synfacts 2005(0): 0061-0061  
DOI: 10.1055/s-2005-869919
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Pd-Catalyzed Allylic Alkylation of Ketones

Contributor(s): Hisashi Yamamoto, Matthew Boxer
B. M. Trost*, J. Xu
Stanford University, USA
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Publication History

Publication Date:
20 July 2005 (online)

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Significance

The synthesis of α-chiral quaternary cyclohexanones has remained a challenge in organic synthesis. This report shows excellent yields with ee’s over 90% for many substrates and thus is an important step for total syntheses.