‘One-Pot’ Zr-Catalyzed Asymmetric Carboalumination-Pd Cross-Coupling

Significance

An efficient all-catalytic asymmetric protocol for the synthesis of α,ω-diheterofunctional reduced polypropionates in one pot has been achieved. Starting from inexpensive styrene, asymmetric Zr-catalyzed carbo-alumination followed by Pd-catalyzed vinylation of the isoalkyl­alanes allows for the construction of reduced polypropionate chains.