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Synfacts 2005(0): 0074-0074  
DOI: 10.1055/s-2005-869924
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Indium-Mediated Asymmetric Allylation of Aldimines in Methanol

Contributor(s): Paul Knochel, Andrei Gavryushin
T. Vilayvan*, C. Winotapan, V. Banphavichit, T. Shinada, Y. Ohfune
Chulalongkorn University, Thailand; Osaka City University, Japan
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Publication History

Publication Date:
20 July 2005 (online)

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Significance

The synthesis of chiral homoallylic amines was easily performed in methanol as a solvent under very mild conditions, thus tolerating a number of functional groups. The reagents and auxiliary used are cheap, and the products can be further transformed into various optically pure products.