Synfacts 2005(1): 0160-0160  
DOI: 10.1055/s-2005-872133
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Asymmetric Conjugate Addition of Arylalkynes to Nitroolefins

Contributor(s): Paul Knochel, Andrei Gavryushin
M. Yamashita, K. Yamada, K. Tomioka*
Kyoto University, Japan
Further Information

Publication History

Publication Date:
21 September 2005 (online)


The asymmetric addition of alkynes to nitroolefins is a useful method of an enantioselective formation of a C-C bond. The nitro function can be easily converted into a ketone or an amine, and the triple bond is readily reduced or oxidized. This approach opens routes to a number of synthetic targets.