Directed Metalation and Cross-Coupling of N,N-Dialkyl Aryl O-Sulfamates
T. K. Macklin, V. Snieckus*
Queen’s University, Kingston, Canada
21 September 2005 (online)
N,N-Dialkyl sulfamate can serve as an ortho-directing group in the metalation reaction as well as a leaving group in Ni-catalyzed cross-coupling. Such properties lead to a powerful synthetic strategy for the preparation of polyfunctionalized arenes and hetarenes, starting from aryl O-sulfamates.