Synfacts 2005(1): 0093-0093  
DOI: 10.1055/s-2005-872146
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Total Synthesis of (-)-Brasoside and (-)-Littoralisone

Contributor(s): Philip Kocienski, Fiona Black
I. K. Mangion, D. W. C. MacMillan*
California Institute of Technology, Pasadena, USA
Further Information

Publication History

Publication Date:
21 September 2005 (online)


Littoralisone (from the plant Verbena littoralis) enhances the neurotrophic properties of nerve growth factor (NGF). Brasoside is believed to be an intermediate in the biosynthesis of Littoralisone. This first total synthesis confirms the relative and absolute stereochemistries of the target molecules.