Synfacts 2005(1): 0100-0100  
DOI: 10.1055/s-2005-872147
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of ABT-100, a Farnesyl Transferase Inhibitor

Contributor(s): Philip Kocienski
M. J. Rozema*, A. W. Kruger, B. D. Rohde, B. Shelat, L. Bhagavatula, J. J. Tien, W. Zhang, R. F. Henry
Abbott Laboratories, North Chicago, USA
Further Information

Publication History

Publication Date:
21 September 2005 (online)


The target molecule inhibits farnesyl transferase, an enzyme required for ras-protein activation that drives uncontrolled cell proliferation in some cancers.