Synfacts 2005(1): 0096-0096  
DOI: 10.1055/s-2005-872151
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Total Synthesis of Tirandalydigin

Contributor(s): Philip Kocienski
Y. Iwata, N. Maekawara, K. Tanino, M. Miyashita*
Hokkaido University, Sapporo, Japan
Further Information

Publication History

Publication Date:
21 September 2005 (online)


The target compound inhibits bacterial DNA-directed RNA polymerase. Major accomplishments in the synthesis were (a) the construction of the acid-labile vinyl epoxide and (b) the construction of the tetramic acid.