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Synfacts 2005(1): 0096-0096
DOI: 10.1055/s-2005-872151
DOI: 10.1055/s-2005-872151
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Total Synthesis of Tirandalydigin
Y. Iwata, N. Maekawara, K. Tanino, M. Miyashita*
Hokkaido University, Sapporo, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. September 2005 (online)
Significance
The target compound inhibits bacterial DNA-directed RNA polymerase. Major accomplishments in the synthesis were (a) the construction of the acid-labile vinyl epoxide and (b) the construction of the tetramic acid.