Total Synthesis of (+)-trans-195A
N. Holub, J. Neidhöfer, S. Blechert*
Technische Universität Berlin, Germany
21 September 2005 (online)
The target molecule is isolated from the species of dendrobatid frog Epipedobates bassier, Dendrobates imitator and Dendrobates variabilis. It is a member of the decahydroquinoline class of alkaloids that exhibit non-competitative blocking of nicotinic receptor channels and inhibitory effects on sodium and potassium transport.