Synfacts 2005(1): 0101-0101  
DOI: 10.1055/s-2005-872154
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Discodermolide Using Solely Substrate-Based Stereocontrol

Contributor(s): Philip Kocienski
I. Paterson*, O. Delgado, G. J. Florence, I. Lyothier, M. O’Brien, J. P. Scott, N. Sereinig
University of Cambridge, UK
Further Information

Publication History

Publication Date:
21 September 2005 (online)


(+)-Discodermolide is isolated from the Caribbean deep sea sponge Discodermia dissoluta. It exhibits immunosuppressive and cell growth inhibitory biological activity and is currently entering clinical trials.