Pd-Catalyzed Asymmetric Allylation of Aldehydes using Allylic Alcohols
S.-F. Zhu, Y. Yang, L.-X. Wang, B. Liu, Q.-L. Zhou*
Nankai University, P. R. of China
21 September 2005 (online)
A palladium-catalyzed asymmetric allylation of aldehydes using an umpolung of π-allylpalladium generated from Pd(0), allylic alcohol and Et3B is reported. The chiral spiro monodentate phosphine ligand has proved to be efficient for many aryl, heteroaryl and alkyl aldehydes. Under these conditions, an anti-homoallylic alcohol was obtained in excellent diastereoselectivity and in generally good ee’s.