Enantioenriched α,β-Unsaturated Lactones via Vinylogous Mukaiyama Aldol
X. Moreau, B. Bazán-Tejeda, J.-M. Campagne*
ICSN-CNRS, Gif-sur-Yvette, France
21 September 2005 (online)
From easily accessible starting materials, a variety of enantioenriched α,β-unsaturated six-membered lactones can be synthesized. This method demonstrates a facile route towards a challenging target. Even ketones with similar flanking substituents led to products with high ee. Neither electron-rich nor electron-poor aromatic ketones were well tolerated; and α,β-unsaturated ketones also gave poor results.