Synfacts 2005(1): 0114-0114  
DOI: 10.1055/s-2005-872198
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Aza-Stilbenes via an Ullmann C-N Coupling Reaction in Ionic Liquids

Contributor(s): Victor Snieckus, Robert Engqvist
Z. Wang, W. Bao*, Y. Jiang
Hangzhou, P. R. of China
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Publication History

Publication Date:
21 September 2005 (online)


The first protocol for the synthesis of aza-stilbenes in an ionic liquid is reported. Although substituent effects have not been widely studied, the reaction proceeds in good to excellent yields at comparable temperatures to standard Ullmann procedure. Since copper-amino acid complexes are known, the function of l-proline is undoubtedly to act as a solubilizing/activating ligand.