Regioselective Hydroamination for the Synthesis of Tricyclic Quinolines
C. S. Yi*, S. Y. Yun, I. A. Guzei
University of Wisconsin-Madison, USA
21 September 2005 (online)
An efficient catalytic C-H bond activation/hydroamination protocol has been developed for the synthesis for tricyclic quinoline derivatives in modest to excellent yields (42-99%) under mild conditions. The reaction shows rapid attainment of complexity with minimum functional group requirement. A catalytically active cationic ruthenium-acetylide complex has been isolated and characterized but not shown to participate in the reaction.