Tetraorganosilicon Reagents for Cross-Coupling Reactions
Y. Nakao*, H. Imanaka, A. K. Sahoo, A. Yada, T. Hiyama*
Kyoto University, Japan
21 September 2005 (online)
The readily accessible and highly stable alkenyl- and aryl[2-(hydroxymethyl)phenyl]dimethylsilanes undergo cross-coupling with aryl and alkenyl iodides under mild conditions in a reaction of broad scope (32 examples) and excellent yields (73-99%). The reaction is adaptable to gram scale, and the cyclic silyl ether is recovered and reused. The latter aspect is the first such demonstration for a cross-coupling reaction.