Synfacts 2005(1): 0144-0144  
DOI: 10.1055/s-2005-916016
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Catalytic Enantioselective Fluorination of Oxindoles

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
Y. Hamashima, T. Suzuki, H. Takano, Y. Shimura, M. Sodeoka*
Tohoku University, Japan
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Publication History

Publication Date:
21 September 2005 (online)


Asymmetric fluorination is an important organic transformation due to the many biologically important drugs that contain this atom. This report introduces a new catalyst system for the introduction of fluorine into the oxindole scaffold. The dimetallic catalyst 1 is shown to be a better catalyst using NFSI as a fluorine source.