Enantioselective Fluorination and Chlorination of Compounds Capable of Two-Point Binding
N. Shibata*, J. Kohno, K. Takai, T. Ishimaru, S. Nakamura, T. Toru*, S. Kanemasa
Nagoya Institute of Technology and Kyushu University, Japan
21 September 2005 (online)
Asymmetric halogenation has emerged as an important organic reaction due to the variety of drugs that contain fluorine and the synthetic utility of chiral carbon centers with chlorine substituents. These authors describe a highly enantioselective protocol catalyzed by a chiral Ni(II) complex.