Asymmetric Couplings of Ketenes with Aldehydes to Generate Enol Esters
C. Schaefer, G. C. Fu*
Massachusetts Institute of Technology, USA
21 September 2005 (online)
The highly enantioselective preparation of α-arylalkanoic acids precursors is described. These compounds are of interest due to biological activity and commercial importance. The products were shown to be easily converted into synthetically useful α-chiral-carboxylic acids or -alcohols via LiOH/H2O2 and NaBH4, respectively.