Proline-Based N-Oxides as Modular Chiral Catalysts for Allylation
J. F. Traverse, Y. Zhao, A. H. Hoveyda*, M. L. Snapper*
Boston College, USA
21 September 2005 (online)
The authors introduce their modular amino acid based N-oxide as an organocatalyst for the allylation of aldehydes. The catalyst is prepared through a simple three-step route providing the N-oxide catalysts in good yield (˜50% for three steps). Good yields (>80%) and ee’s in the range of 71-92% are obtained for a number of aromatic aldehydes.