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Synfacts 2005(2): 0237-0237  
DOI: 10.1055/s-2005-916104
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Asymmetric Sulfoxidation with Hydrogen Peroxide in Water

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
A. Scarso, G. Strukul*
Università Cà Foscari di Venezia, Italy
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Publication History

Publication Date:
25 October 2005 (online)

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Significance

Water as a solvent provides perhaps the most ideal conditions pertaining to toxicity, environmental protection and cost. This paper describes the first sulfoxidation of thioethers with water as the solvent and uses the cost- and atom- economical hydrogen peroxide as the oxidant. A low platinum:BINAP catalyst loading (1 mol%) provides yields above 90%.