Synfacts 2006(1): 0011-0011  
DOI: 10.1055/s-2005-921668
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Viridiofungin A

Contributor(s): Philip Kocienski, Fiona Black
A. Pollex, A. Millet, J. Müller, H. Hiersemann*, L. Abraham
Technische Universät Dresden, Germany
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Publikationsverlauf

Publikationsdatum:
16. Dezember 2005 (online)

Significance

Viridiofungins are secondary metabolites isolated from the fungi Trichoderma viride and belong to the alkyl citrate family of compounds. They demonstrate potent fungicidal activity which is due to multiple modes of action. These natural products may also have anti-cancer activity. The synthesis of the triesters of the natural and nonnatural diastereomers of viridiofungin A, A2 and A4 is reported.