A Direct Zincation of Amides, Phosphonates and Phosphine Oxides

M. L. Hlavinka; J. F. Greco; J. R. Hagadorn

doi:10.1055/s-2005-921730

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Synfacts 2006(1): 0060-0060
DOI: 10.1055/s-2005-921730

Metal-Mediated Synthesis

A Direct Zincation of Amides, Phosphonates and Phosphine Oxides

Contributor(s): Paul Knochel, Andrei Gavryushin
M. L. Hlavinka, J. F. Greco, J. R. Hagadorn*
University of Colorado, Boulder, USA

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Publication History

Publication Date:
16 December 2005 (online)

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Significance

Organozinc compounds are important intermediates in modern organic synthesis. This work describes the direct metallation of some amides, phosphine oxides and phosphonates using commercially available diphenylzinc in the presence of secondary amines.