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Synfacts 2006(4): 0306-0306  
DOI: 10.1055/s-2006-932031
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-Ochromycinone and(+)-Rubiginone B2

Contributor(s): Philip Kocienski, Fiona Black
K. Sato, N. Asao*, Y. Yamamoto
Tohoku University, Sendai, Japan
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Publikationsdatum:
24. März 2006 (online)

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Significance

The skeleton of the angucyclinone antibiotics (+)-Ochromycinone and (+)-Rubiginone B2 was constructed using an efficient gold-catalyzed intramolecular [4+2] benzannulation. This 2,3-dihydrophenanthren-4(1H)-one core is found in a number of biologically active natural products.