Synfacts 2006(10): 1045-1045  
DOI: 10.1055/s-2006-949308
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Reductive Carboamination of Olefins with Aryldiazonium Salts

Contributor(s): Paul Knochel, Andrei Gavryushin
M. R. Heinrich*, O. Blank, S. Wölfel
Technische Universität München, Garching, Germany
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Publikationsverlauf

Publikationsdatum:
21. September 2006 (online)

Significance

Although the use of diazonium salts in the addition reaction to olefins has been known for a long time, this process was limited to electron-deficient alkenes. The authors developed for the first time a procedure which allows the functionalization of non-activated terminal alkenes bearing functional groups. This is a very simple and elegant method, allowing the fast assembly of complex polyfunctional molecules starting from inexpensive substituted anilines. Obviously, this method will soon find a broad application in the synthesis of biologically active compounds.