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Synfacts 2007(2): 0221-0221  
DOI: 10.1055/s-2006-955772
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Silsesquioxane-Bound Molybdenum Catalyst for Alkyne Metathesis

Contributor(s): Yasuhiro Uozumi, Takayasu Arakawa
H. M. Cho, H. Weissman, S. R. Wilson, J. S. Moore*
University of Illinois at Urbana-Champaign, USA
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Publication History

Publication Date:
23 January 2007 (online)

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Significance

A silsesquioxane-bound molybdenum catalyst for alkyne metathesis was prepared from Mo(VI) precatalyst 1 and silsesquioxane 2. This catalyst was applied to the ring-closing alkyne metathesis (RCAM) and the cyclooligomerization reaction. RCAM of diyne 3 with 1 and 2 gave a mixture of the monomeric macrocycle 4 and the dimeric macrocycle 5 under vacuum-driven conditions. Tetrameric macrocycle 7 was obtained in high isolated yield via alkyne metathesis of substrate 6 using 1 and 2 under precipitation-driven conditions.