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Synfacts 2007(2): 0207-0207
DOI: 10.1055/s-2006-955793
DOI: 10.1055/s-2006-955793
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart · New York
Enantioselective S-Chiral Sulfinamide Catalyzed Reduction of Ketimines
D. Pei, Z. Wang, S. Wei, Y. Zhang, J. Sun*
Chengdu Institute of Biology and Xihua University, Chengdu, P. R. of China
Further Information
Publication History
Publication Date:
23 January 2007 (online)
Significance
The authors developed an easily accessible chiral sulfinamide (1) and successfully used it for the asymmetric reduction of a broad range of N-aryl ketimines 2 with trichlorosilane to synthesize optically active amines 3 in high yields and enantiomeric excesses.