Synfacts 2007(2): 0171-0171  
DOI: 10.1055/s-2006-955837
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Reductive Aldol Reaction of Allenic Esters to Ketones

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
D. Zhao, K. Oisaki, M. Kanai*, M. Shibasaki*
The University of Tokyo, Japan
Further Information

Publication History

Publication Date:
23 January 2007 (online)

Significance

The development of chiral tertiary alcohols via C-C bond formation is constantly under scrutiny due to the valued promise of these intermediates in biologically active and pharmaceutical products. In this continued work on the reductive aldol reaction of allenic esters to ketones, the authors expand the substrate scope. Changing the conditions slightly enhances the regio­selectivity significantly over previous results (Tetrahedron Lett. 2006, 47, 1403-1407).