Download PDF
Synfacts 2007(2): 0172-0172  
DOI: 10.1055/s-2006-955844
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Conjugate Addition of Et-2Zn to α,β-Unsaturated Imines

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
F. Palacios*, J. Vicario
Universidad del País Vasco, Vitoria-Gasteiz, Spain
Further Information

Publication History

Publication Date:
23 January 2007 (online)

    Permissions and Reprints

Significance

This paper describes the relatively rigorous optimization for the copper-catalyzed conjugate addition of diethylzinc to α,β-unsaturated imines. A variety of BINOL-type and TADDOL-type phosphoramidite ligands were tested with 1 giving the highest ee values in the initial screening. Toluene proved to be the best solvent and Cu(MeCN)4PF6 was the best copper source.