Synfacts 2007(3): 0311-0311  
DOI: 10.1055/s-2007-968174
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Enantioselective Intramolecular Addition of Arylboronic Acids to Ketones

Contributor(s): Paul Knochel, Andrei Gavryushin
G. Liu, X. Lu*
Shanghai Institute of Organic Chemistry, P. R. of China
Further Information

Publication History

Publication Date:
20 February 2007 (online)

Significance

This work represents the first report on a Pd-catalyzed asymmetric arylation of simple ketones. It affords a simple technique for the highly enantioselective preparation of fused cyclo­alkanols. The products are useful intermediates in the synthesis of various biologically active molecules. This method has also good perspectives for a further development in order to perform an intermolecular version of this type of arylation reaction.