Multicomponent Domino Reaction

Significance

An amine-catalyzed enantioselective multicomponent domino reaction leading to substituted cyclohexene carbaldehydes 4 is reported. These products are assumed to be formed via an iminium-iminium-enamine catalysis sequence, starting from two equivalents of an α,β-un­saturated aldehyde (1 = 2) and different activated methylene compounds 3. All products are formed in good diastereomeric ratios and excellent enantioselectivities. Notably, also two different α,β-unsaturated aldehydes (1 ≠ 2) are well tolerated.