Synfacts 2007(5): 0536-0536  
DOI: 10.1055/s-2007-968423
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Cu-Catalyzed Coupling of Grignard Reagents with Primary Alkyl Halides

Contributor(s): Paul Knochel, Andrei Gavryushin
J. Terao*, H. Todo, S. A. Begum, H. Kuniyasu, N. Kambe*
Osaka University, Japan
Further Information

Publication History

Publication Date:
24 April 2007 (online)


The authors report herein a simple and convenient method for the cross-coupling reaction between alkyl and aryl Grignard reagents and primary alkyl halides or sulfonates. It allows a simple preparation of substituted acyclic hydrocarbons, bearing functions tolerated by organomagnesium reagents. The synthetic protocol is quite simple and affords usually almost quantitative yields of products. This new approach, using Cu-alkyne species as catalysts for the cross-coupling reaction is extremely promising for future investigations.