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Synfacts 2007(5): 0527-0527  
DOI: 10.1055/s-2007-968430
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Three Different Pathways in Ni-Catalyzed Reductive Aldol Reactions

Contributor(s): Paul Knochel, Tobias Thaler
C. C. Chrovian, J. Montgomery*
University of Michigan, Ann Arbor, USA
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Publikationsdatum:
24. April 2007 (online)

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Significance

This comprehensive study on Ni-catalyzed reductive aldol reactions demonstrates how the outcome of a multi-component reaction can be influenced by the choice of the reducing agent and the Ni catalyst. A mechanism for the Ni(0)-catalyzed reductive aldol reaction is also proposed enlightening the role of the iodobenzene and postulating a Ni(II) intermediate.