Synfacts 2007(5): 0521-0521  
DOI: 10.1055/s-2007-968463
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Phosphordiamidite Ligands in Iridium-Catalyzed Allylic Etherification

Contributor(s): Hisashi Yamamoto, Joshua N. Payette
M. Kimura, Y. Uozumi*
Institute for Molecular Science, Okazaki, Japan
Further Information

Publication History

Publication Date:
24 April 2007 (online)


Phosphoramidite ligands have found numerous applications in metal-catalyzed asymmetric reactions. This report focuses on the less-known class of chiral phosphordiamidite ligands. Ten types of these ligands have been preliminarily screened in the iridium-catalyzed allylic etherification. DFT calculations of π-allyliridium intermediates provide explanation for the observed reverse facial selectivity upon switching the P- and N-substituents.