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Phosphordiamidite Ligands in Iridium-Catalyzed Allylic Etherification
M. Kimura, Y. Uozumi*
Institute for Molecular Science, Okazaki, Japan
24 April 2007 (online)
Phosphoramidite ligands have found numerous applications in metal-catalyzed asymmetric reactions. This report focuses on the less-known class of chiral phosphordiamidite ligands. Ten types of these ligands have been preliminarily screened in the iridium-catalyzed allylic etherification. DFT calculations of π-allyliridium intermediates provide explanation for the observed reverse facial selectivity upon switching the P- and N-substituents.