Synthesis of Durgamone, Nakorone and Abudinol B

R. Tong; J. C. Valentine; F. E. McDonald; R. Cao; X. Fang; K. I. Hardcastle

doi:10.1055/s-2007-968508

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Synfacts 2007(6): 0572-0572
DOI: 10.1055/s-2007-968508

Synthesis of Natural Products and Potential Drugs

Synthesis of Durgamone, Nakorone and Abudinol B

Contributor(s): Philip Kocienski, Fiona Black
R. Tong, J. C. Valentine, F. E. McDonald*, R. Cao, X. Fang, K. I. Hardcastle
Emory University, Atlanta, USA

Further Information

Publication History

Publication Date:
22 May 2007 (online)

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Significance

Abudinol B is a triterpenoid isolated from the Red Sea sponge Ptilocaulis spiculifer along with the oxidative degradation products durgamone and nakorone. Biomimetic cascade cyclization reactions were used to synthesize all three natural products.