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Synfacts 2007(6): 0568-0568  
DOI: 10.1055/s-2007-968519
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (±)-Strychnine

Contributor(s): Philip Kocienski, Zofia Komsta
H. Zhang, J. Boonsombat, A. Padwa*
Emory University, Atlanta, USA
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Publication History

Publication Date:
22 May 2007 (online)

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Significance

Strychnine is a monoterpenoid indole alkaloid. The key step of this synthesis is an intramolecular [4+2] cycloaddition-rearrangement cascade of an indolyl-substituted amidofuran.