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Synfacts 2007(6): 0563-0563  
DOI: 10.1055/s-2007-968521
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Pleocarpenene

Contributor(s): Philip Kocienski, Thomas Snaddon
M. J. Williams, H. L. Deak, M. L. Snapper*
Boston College, Chesnut Hill, USA
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Publication History

Publication Date:
23 May 2007 (online)

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Significance

Pleocarpenene is a guaiane natural product. Snapper and co-workers used (1) an intramolecular cyclobutadiene cycloaddition reaction and (2) a thermal ring fragmentation reaction en route to the 5-7-fused ring system.