Synthesis of Substituted Pyrroles via Cu-Catalyzed Vinylation of Hydrazides

Significance

Pyrroles are found in many naturally occurring molecules. They are also widely used in modern material science. The authors developed a new convenient synthesis of polysubstituted pyrroles, consisting of a novel Cu-catalyzed bis-vinylation of Boc-hydrazines followed by the Piloty-Robinson rearrangement-cyclization of ketazines. It allows a flexible and regioselective preparation of a variety of functionalized pyrroles from simple and readily available precursors.