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Synfacts 2007(7): 0676-0676
DOI: 10.1055/s-2007-968600
DOI: 10.1055/s-2007-968600
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Phalarine
C. Li, C. Chan, A. C. Heimann, S. J. Danishefsky*
Sloan-Kettering Institute for Cancer Research and Columbia University, New York, USA
Further Information
Publication History
Publication Date:
22 June 2007 (online)
Significance
Phalarine is a synthetically challenging furanobisindole alkaloid. Key to this synthesis is the cascade formation of F by rearrangement of azaspiroindolenine D. For a mechanistic discussion of this process, see: S. J. Danishefsky and co-workers Angew. Chem. Int. Ed. 2007, 46, 1444-1447.