Synfacts 2007(7): 0672-0672  
DOI: 10.1055/s-2007-968604
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-Madindolines A and B

Contributor(s): Philip Kocienski, Zofia Komsta
L. Wan, M. A. Tius*
University of Hawaii and the Cancer Research Center of Hawaii, Honolulu, USA
Further Information

Publication History

Publication Date:
22 June 2007 (online)

Significance

Madindolines A and B selectively inhibit growth of interleukine-6 dependent cells. The main steps of this synthesis are (1) an allene-ether Nazarov cyclization and (2) an intermolecular Mannich reaction.