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Synfacts 2007(7): 0677-0677  
DOI: 10.1055/s-2007-968606
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-3-(Z)-Laureatin

Contributor(s): Philip Kocienski, Thomas Snaddon
H. Kim, H. Lee, D. Lee, S. Kim, D. Kim*
Seoul National University, Korea
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Publication History

Publication Date:
22 June 2007 (online)

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Significance

(+)-3-(Z)-Laureatin is a marine dioxa­bicyclic oxocene with insecticidal activity against malaria-transmitting mosquitos. This synthesis is notable for its use of substrate conformation to direct the diastereoselectivity of reactions.