Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2007(7): 0671-0671
DOI: 10.1055/s-2007-968610
DOI: 10.1055/s-2007-968610
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of (-)-Cribrostatin 4
G. Vincent, R. M. Williams*
Colorado State University, Fort Collins and the University of Colorado Cancer Center, Aurora, USA
Further Information
Publication History
Publication Date:
22 June 2007 (online)
Significance
Cribrostatin 4 displays low-micromolar cytotoxicity and antibacterial activity. The key step in the synthesis depicted is the reductive cleavage/elimination of the β-lactam in I followed by Pictet-Spengler cyclization of the intermediate iminium ion J.