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Synfacts 2007(7): 0716-0716  
DOI: 10.1055/s-2007-968617
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Sugar-Diphosphoamidite Ligands for Palladium-Catalyzed Allylic Alkylations

Contributor(s): Mark Lautens, Michael Langer
E. Raluy, M. Diéguez*, O. Pàmies*
Universitat Rovira i Virgili, Tarragona, Spain
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Publication History

Publication Date:
22 June 2007 (online)

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Significance

The enantioselective formation of carbon-carbon bonds is one of the most important reactions in organic synthesis. The palladium-mediated allylic alkylation is a well-understood example for this reaction and a large number of chiral ligands have been developed. The authors report the first example of diphosphoamidite ligands attached to a readily available carbo­hydrate backbone which leads to a highly modular ligand class for allylic alkylations (previous work: Adv. Synth. Catal. 2005, 347, 1257-1266.)