Arylation of Heterocycles via C-H Activation and Cross-Coupling with Aryl Chlorides

Significance

A new cheap and general method for the cross-coupling of heterocycles is presented in this article. A wide range of heterocycles was subjected to Pd-catalyzed C-H activation with subsequent cross-coupling to aryl and heteroaryl chlorides. This method was shown to be applicable to both electron-rich and electron-poor aryl chlorides furnishing good yields in almost all cases.