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Synfacts 2007(8): 0786-0786  
DOI: 10.1055/s-2007-968709
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-ξ-Clausenamide and(-)-Balasubramide

Contributor(s): Philip Kocienski, Zofia Komsta
L. Yang, G. Deng, D.-X. Wang, Z.-T. Huang, J.-P. Zhu, M.-X. Wang*
Beijing National Laboratory for Molecular Sciences, P. R. of China and Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France
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Publication History

Publication Date:
24 July 2007 (online)

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Significance

(±)-ξ-Clausenamide and (-)-balasubramide are alkaloids isolated from Clausena sp. trees, the leaves and fruit of which are used in folk medicine. In nature these products are most likely formed from (+)-SB204900 by the intramolecular 8-endo-aryl-epoxide cyclization.