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Synfacts 2007(8): 0783-0783
DOI: 10.1055/s-2007-968720
DOI: 10.1055/s-2007-968720
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Spirotenuipesine A
M. Dai, S. J. Danishefsky*
Columbia University and Sloan-Kettering Institute for Cancer Research, New York, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
24. Juli 2007 (online)
Significance
Spirotenuipesines A and B are isolated from the Paecilomuyces tenuipes fungus. They show activity against 1321N1 human astrocytoma cells by inducing discharge of neurotrophic factors. Key to this synthesis is an intermolecular Diels-Alder reaction to prepare a spiroenone (G to I).