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Synfacts 2007(8): 0832-0832
DOI: 10.1055/s-2007-968768
DOI: 10.1055/s-2007-968768
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Enantioselective Rh-Catalyzed Intermolecular Hydroacylation
R. T. Stemmler, C. Bolm*
RWTH Aachen, Germany
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
24. Juli 2007 (online)
Significance
The authors report the first asymmetric rhodium-catalyzed intermolecular hydroacylation reaction. It is found that monodentate phosphine ligands give endo products while bidentate phosphine give exo products selectively. Interestingly, even the minor exo isomers obtained from monodentate ligands are formed in consistently higher ee values than the corresponding endo isomers.